报告题目：On the Within-host Dynamics of HIV Infection

报告人: Professor Shigui Ruan, University of Miami, USA

邀请人：吴事良 教授、刘丹 副教授、张丽 副教授

报告时间：2017年6月8日16：00-17：00

报告地点：信远楼II206数统院报告厅

报告摘要： In this talk, I will review some basic concepts and models on the within-host dynamics of HIV infection. Then I will introduce some recent studies on the global dynamics of the within-host HIV infection, one is an age-structured virus dynamics model with Beddington-DeAngelis infection function and the other is an infection model with both virus-to-cell and cell-to-cell transmissions and three distributed delays, in which the first distributed delay describes the intracellular latency for the virus-to-cell infection, the second delay represents the intracellular latency for the cell-to-cell infection, and the third delay describes the time period that viruses penetrated into cells and infected cells release new virions. Global stability analyses of both models are carried out in terms of the basic reproduction number. Examples and numerical simulations for several special cases are presented, including various within-host dynamics models with discrete or distributed delays that have been well-studied in the literature.

报告人简介：阮士贵教授于1992年在加拿大阿尔伯特（Alberta）大学获得应用数学博士学位。1994-2002在加拿大道尔豪斯(Dalhousie)大学数学与统计系工作，先后任助理教授和副教授。从2002年起至今在美国迈阿密大学(University of Miami)数学系工作，并于2005年起任教授至今。阮士贵教授的主要研究领域是动力系统和微分方程及其在生物和医学中的应用，发表的论文的多达近两百篇，受到了国内外同行的关注与大量引用。阮教授对一些在传染病（如非典、乙型肝炎、血吸虫感染、狂犬病、疟疾、院内感染等）的数学建模、数据模拟和理论分析作了一系列开创性工作，这些工作不但填补了该领域的科研空白，而且对理解和控制这些传染病在我国的流行和传播有着非常重要的现实意义。阮教授担任生物数学领域重要期刊《Mathematical Biosciences》、《Discrete and Continuous Dynamical Systems - Series B》、《Mathematical Biosciences and Engineering》等重要期刊编委。